Six hail weather processes occurred in western Guizhou from late April to early May 2022, and there were four hail disasters affected the red cartridge kiwifruit production seriously in western Guizhou. The four hail disasters occurred on 22 April, 6 May, 8 May, and 9 May. In order to investigate the effects of four hail weather processes from late April to early May 2022 on red cartridge kiwifruit, the characteristics data of six hail processes and the disaster situation of red cartridge kiwifruit by four hail disasters were obtained by the investigation of the regions affected by six hail weather processes. Both the characteristics of atmospheric circulation induced by hail weather were analyzed, and the loss of red cartridge kiwifruit caused by four hail disasters was assessed by statistical method. The results showed that the maximum hail diameter reached 20 mm, but most of the maximum hail diameter was below 10 mm, in six hail weather processes. Among them, both the maximum hail diameter in Shuicheng District was larger than that in other district, and the number of hail weather process was also the most. The weather background of the four hail weather processes affecting red cartridge kiwifruit production had the common characteristics that the value of CAPE of Guiyang station was much higher than that of Weining station, the relative humidity of middle-low levels was above 90%, and the relative humidity of middle-high levels was about 80%.Before the hail weather occurred on 22 April, 6 May and 9 May, shallow trough at 500hPa and low vortex shear line at 700hPa was observed in western Guizhou. Before the hail weather occurred on 8 May, west Guizhou was in the periphery of the West Pacific Subtropical High at 500hPa and 700hPa.Four hail disasters resulted 885.4 hectares of red cartridge kiwifruit demolished no harvest, and it accounts for 9.04% of base’s planting areas of red cartridge kiwifruit in western Guizhou. Due to four hail disaster, the yield loss of red cartridge kiwifruit was about 13,300 tons, and the direct economic loss was 199,215,000 yuan.