Based on the daily meteorological fog data and NCEP/NCAR FNL 1°x1° reanalysis data from 1980 to 2017, the spatial-temporal distribution characteristics of fog in Quzhou City of Zhejiang Province were analyzed by statistical method, synoptic method and cumulative frequency method. ①The results show that occurrence frequency of fog are higher in mountainous area than that in Plain area, and northern areas experience more fog days than the southern areas; fog mainly occurs in winter and spring，and 83.2% of fog occurs from 23∶00 to 9∶00 the next day, reaching the peak at 6∶00. ②It turns out that four types of surface synoptic situation can lead to regional fog in Quzhou , which are the warming zone in front of the cold front, continental high, high pressure aft-part over sea, low trough, and three types of synoptic situation at 500 hPa, can also lead to regional fog, which are zonal flow, low trough, high pressure ridge. ③Usually the lower troposphere exhibit the characteristic of high humidity and slight breeze the day before fog occurs, and there is an inversion layer close to the ground when low trough dominates, while the inversion layers are away from the surface layer during the other three types of situation. ④For the comprehensive analysis of meteorological elements in foggy days, the thresholds and negative indexes of relative humidity, wind speed, temperature inversion are determined by the cumulative frequency method. ⑤After two years of application, the forecast model has an accuracy of 71.2%, with good prospects in operational weather forecast.