Based on the O3 monitoring data and meteorological observation data in Meizhou from 2014 to 2017, the change characteristics of O3 in the region and the meteorological conditions affecting O3 were analyzed. It shows that: The numbers of non-attainment day of ozone maintain a stable leve in Meizhou area from 2014 to 2017, the secondary level non-attainment days of ozone are concentrated in spring and summer; The proportion of ozone concentration non-attainment days in AQI concentration non-attainment days increased rapidly, the secondary level non-attainment days of ozone mainly occurred from March to August, the most in April, ozone is an important factor affecting Meizhou urban air quality. The monthly average concentration of O3 was significantly positively correlated with the same temperature and sunshine, negatively correlated with pressure over the same period; the process of ozone pollution, the daily concentration of O3 with the same temperature and sunshine was significantly positively correlated, negatively related to total cloudiness, with the same period of low cloudiness and humidity; the process of ozone pollution, ozone concentration and the ground and high altitude weather situation configuration is closely related to changes of ozone concentration is the interaction of various meteorological elements results.